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Following the exclusion of reports with incomplete methodologies, 93 studies were ultimately selected for comprehensive analysis
In addition, differences in the initial situation of gastric emptying, which is a measure of the effectiveness of GLP- 1- receptor co-agonists, are likely to have a different effect on patients with obesity than on people in whom preoperative intragastric food retention after taking GLP- 1 receptor co-agonists is not impaired, and in people with diabetes [127]
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We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]
191,192 In vascular endothelial cells, GLP-1R activation stimulates endothelial nitric oxide synthase (eNOS), promoting nitric oxide (NO) production and improving endothelium-dependent vasodilation
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